AMGEN OA-ANZBMS Clinical Grant Program 2018
Dr Vinicius Cavalheri, PhD
Senior Lecturer and Evidence-Based Physiotherapy Projects Coordinator, School of Physiotherapy and Exercise Science, Curtin University
‘Addressing the weakening of bones commonly seen in people with chronic obstructive pulmonary disease.’
Patients with chronic lung disease have weak bones and, when compared with healthy people, they have a higher chance of dying if they break their hip during a fall. Jumping-type exercises may improve the strength of their bones, and this project will look to see if these exercises are possible.
In patients with chronic lung disease referred to lung rehabilitation programs that include exercise training, we will add a prescription of jumping-type exercises such to be performed during the 8 weeks of the rehabilitation program and supervised by a physiotherapist. Following the end of the lung rehabilitation program, jumping exercises will also be performed at home, four times per week for 32 weeks.
The study will assess whether the jumping exercises can be tolerated by patients and investigate changes in bone strength and balance after the 40-week program.
This study will provide initial evidence on the effectiveness of incorporating jumping-type exercises into lung rehabilitation programs to improve bone health and balance in this patient group, thereby potentially reducing both the risk of breaking their hip/leg during a fall and subsequent risk of dying after breaking their hip/leg.
Associate Professor Chris White
Area Director of Research, South Eastern Sydney Local Health District
‘Early Identification of Patients at risk from Osteoporosis’
The project addresses the issues associated with early identification of patients at risk of secondary fractures with undiagnosed osteoporosis. Early identification of such patients followed by appropriate investigations and therapy will reduce the burden of the disease to both individuals and society through reduction of the morbidity and mortality associated with the disease.
The project will analyse over 3,000 radiology reports (originating from the Dubbo epidemiological study) by a tool designed to read radiology reports in real time and identify all reports in which a fracture is either directly or incidentally reported. Analysis of the reports from the epidemiological study, where fractures and their impact have already been identified, will provide an accurate and efficient methodology for verification of the specificity and sensitivity of this tool.
The aim is people suffering from osteoporosis at the highest risk of a second fracture will be identified early and appropriately investigated. Those diagnosed with the disease will be offered treatment regimes to reduce the progress of their disease, limit the rate of re-fracture and provide them with an improved quality of life.
Associate Professor Nigel Toussaint
Deputy Director of Nephrology, Department of Nephrology, The Royal Melbourne Hospital
‘NAB-CKD Study (Non-invasive Assessment of Bone health in Chronic Kidney Disease).’
Developing novel screening and management tools for osteoporosis and fracture risk in people with both chronic kidney disease (CKD) and osteoporosis assumes considerable importance given the global burden of kidney disease. This project uses an innovative non-invasive measurement of bone microarchitecture with magnetic resonance imaging (MRI) to assess osteoporosis and other bone diseases in people with CKD and evaluate its clinical usefulness to potentially reduce fracture.
This project aims to assess bone microarchitecture with magnetic resonance imaging (MRI) scans in patients with osteoporosis and chronic kidney disease (CKD) and compare bone microarchitecture with commonly used osteoporosis tests - bone turnover markers (from blood tests) and bone mineral density (from bone density scans). The MRI images will also be correlated with clinical outcomes, such as fractures, over 3 years, to improve the long-term management of osteoporosis and bone disease in patients with CKD.
Knowledge of the development and progression of osteoporosis (or other bone diseases) in chronic kidney disease (CKD) is relatively poor given difficulties in diagnosis. We endeavour to establish and validate the use of MRI scans for the determination of bone microarchitecture in CKD. This will support the clinical application of MRI in helping direct therapies towards the management of osteoporosis (and other bone diseases) in patients with CKD.
Professor Philip Sambrook Young Investigator Travel Award 2018
Dr Feitong Wu
Menzies Institute for Medical Research, University of Tasmania
Area of research to be presented ‘Associations of measured sedentary time and physical activities with muscle strength, balance and falls in Australian middle-aged women’