AMGEN OA-ANZBMS Clinical Grant Program 2019
Dr Ayse Zengin, PhD
Research Fellow, Monash University
‘Study of Indigenous Bone and Muscle Ageing (SIMBA).’
Minimal trauma hip fractures occur at a younger age and higher rates in Indigenous vs nonIndigenous-Australians. With lower life expectancy, age onset of bone loss is unknown in Indigenous-Australians. Data collected will inform the best “window of opportunity” regarding when to test for osteoporosis in Indigenous-Australians to reduce fracture prevalence.
This project will provide data regarding the age of osteoporosis onset in Indigenous-Australians aged >35 years. This will enable testing for osteoporosis at the most appropriate age, accurate osteoporosis diagnosis and fracture risk assessment. Together these will prevent fracture and enable older Indigenous-Australians to remain in community and on Country.
Professor Gustavo Duque MD, PhD, FRACP, FGSA
Chair of Medicine and Director of AIMSS, The University of Melbourne
‘A new strategy to prevent fractures in Australian nursing homes’
Hip fractures are devastating for older adults living in residential aged care facilities (RACF) and result in reduced quality of life, loss of mobility, and increased death rates. Considering that in Australia osteoporosis in RACF residents is underdiagnosed and undertreated, we aim to increase the identification and treatment of osteoporosis in Australian RACF.
To increase risk identification, we will develop and evaluate an electronic version (app) of the Fracture Risk Scale (FRS) to be installed in the mobile devices of GPs practising in RACF in Western Melbourne. We will go further by integrating fracture risk Clinical Assessment Protocols (CAPs), which will be part of the admission process and will provide recommendations tailored for specific RACF residents. These recommendations will help care providers understand fracture risk and guide them in giving the appropriate treatments and using strategies demonstrated to prevent fractures.
These recommendations will help care providers understand fracture risk, and guide them in giving the appropriate treatments and using strategies demonstrated to prevent fractures
Professor Philip Sambrook Young Investigator Travel Award 2019
Austin Health, The University of Melbourne
This year, Sabashini took up an opportunity to expand on her previous research in osteoporosis therapeutics by undertaking a research fellowship with Dr Leder’s lab at the Massachusetts General Hospital, Harvard University, USA. So far, her work has involved the use of monotherapy to prevent bone loss. Here, she will evaluate the use of combination therapy and gain insights into how these therapies work together to improve skeletal integrity. This consolidated with her knowledge in the use of bone remodelling markers and bone imaging she hopes to learn new skills such as the use of finite element analysis and bone histomorphometry.